In vivo corneal high-speed, ultra-high-resolution optical coherence tomography

Viki Christopoulos, Larry Kagemann, Gadi Wollstein, Hiroshi Ishikawa, Michelle L. Gabriele, Maciej Wojtkowski, Vivek Srinivasan, James G. Fujimoto, Jay S. Duker, Deepinder K. Dhaliwal, Joel S. Schuman

    Research output: Contribution to journalArticle

    Abstract

    Objective: To introduce new corneal high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT) technology that improves the evaluation of complicated and uncomplicated cataract, corneal, and refractive surgical procedures. Design: This case series included a control subject and 9 eyes of 8 patients who had undergone phacoemulsification, Descemet membrane stripping endokeratoplasty, corneal implantation for keratoconus, and complicated and uncomplicated laser in situ keratomileusis. These eyes underwent imaging using a prototype ophthalmic hsUHR-OCT system. All the scans were compared with conventional slitlamp biomicroscopy. Results: Cross-sectional hsUHR-OCT imaging allowed in vivo differentiation of corneal layers and existing pathologic abnormalities at ultrahigh axial image resolution. These images illustrate the various incisional and refractive interfaces created with corneal procedures. Conclusions: The magnified view of the cornea using hsUHR-OCT is helpful in conceptualizing and understanding basic and complicated clinical pathologic features; hsUHR-OCT has the potential to become a powerful, noninvasive clinical corneal imaging modality that can enhance surgical management. Trial Registration: clinicaltrials.gov Identifier: NCT00343473.

    Original languageEnglish (US)
    Pages (from-to)1027-1035
    Number of pages9
    JournalArchives of Ophthalmology
    Volume125
    Issue number8
    DOIs
    StatePublished - Aug 2007

    ASJC Scopus subject areas

    • Ophthalmology

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  • Cite this

    Christopoulos, V., Kagemann, L., Wollstein, G., Ishikawa, H., Gabriele, M. L., Wojtkowski, M., Srinivasan, V., Fujimoto, J. G., Duker, J. S., Dhaliwal, D. K., & Schuman, J. S. (2007). In vivo corneal high-speed, ultra-high-resolution optical coherence tomography. Archives of Ophthalmology, 125(8), 1027-1035. https://doi.org/10.1001/archopht.125.8.1027