In Vivo Evaluation of a Novel Implant Coating Agent: Laminin-1

Kostas Bougas, Ryo Jimbo, Stefan Vandeweghe, Nick Tovar, Marta Baldassarri, Ali Alenezi, Malvin Janal, Paulo G. Coelho, Ann Wennerberg

Research output: Contribution to journalArticlepeer-review


Purpose: The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo. Materials and Methods: Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1. Results: After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone. Conclusions: Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.

Original languageEnglish (US)
Pages (from-to)728-735
Number of pages8
JournalClinical Implant Dentistry and Related Research
Issue number5
StatePublished - Oct 1 2014


  • Biochemical coating
  • Implants
  • Laminin-1
  • Titanium

ASJC Scopus subject areas

  • Oral Surgery
  • General Dentistry


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