In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography

Bo Wang, Jessica E. Nevins, Zach Nadler, Gadi Wollstein, Hiroshi Ishikawa, Richard A. Bilonick, Larry Kagemann, Ian A. Sigal, Ireneusz Grulkowski, Jonathan J. Liu, Martin Kraus, Chen D. Lu, Joachim Hornegger, James G. Fujimoto, Joel S. Schuman

    Research output: Contribution to journalArticle

    Abstract

    PURPOSE: The lamina cribrosa (LC) is a prime location of glaucomatous damage. The purpose of this study was to compare LC 3-dimensional micro-architecture between healthy and glaucomatous eyes in vivo by using optical coherence tomography (OCT).

    METHODS: Sixty-eight eyes (19 healthy and 49 glaucomatous) from 47 subjects were scanned in a 3.5 × 3.5 × 3.64-mm volume (400 × 400 × 896 pixels) at the optic nerve head by using swept-source OCT. The LC micro-architecture parameters were measured on the visible LC by an automated segmentation algorithm. The LC parameters were compared to diagnosis and visual field mean deviation (VF MD) by using a linear mixed effects model accounting for age.

    RESULTS: The average VF MD for the healthy and glaucomatous eyes was -0.50 ± 0.80 dB and -7.84 ± 8.75 dB, respectively. Beam thickness to pore diameter ratio (P = 0.04) and pore diameter standard deviation (P < 0.01) were increased in glaucomatous eyes. With worse MD, beam thickness to pore diameter ratio (P < 0.01), pore diameter standard deviation (P = 0.05), and beam thickness (P < 0.01) showed a statistically significant increase while pore diameter (P = 0.02) showed a significant decrease. There were no significant interactions between any of the parameters and age (all P > 0.05).

    CONCLUSIONS: Glaucomatous micro-architecture changes in the LC, detected by OCT analysis, reflect beams remodeling and axonal loss leading to reduction in pore size and increased pore size variability.

    Original languageEnglish (US)
    Pages (from-to)8270-8274
    Number of pages5
    JournalInvestigative ophthalmology & visual science
    Volume54
    Issue number13
    DOIs
    StatePublished - Dec 1 2013

    Keywords

    • glaucoma
    • lamina cribrosa
    • optical coherence tomography

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems
    • Cellular and Molecular Neuroscience

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  • Cite this

    Wang, B., Nevins, J. E., Nadler, Z., Wollstein, G., Ishikawa, H., Bilonick, R. A., Kagemann, L., Sigal, I. A., Grulkowski, I., Liu, J. J., Kraus, M., Lu, C. D., Hornegger, J., Fujimoto, J. G., & Schuman, J. S. (2013). In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography. Investigative ophthalmology & visual science, 54(13), 8270-8274. https://doi.org/10.1167/iovs.13-13109