In vivo optical biopsy of the human retina using optical coherence tomography

W. Drexler, R. K. Ghanta, J. S. Schuman, T. Ko, U. Morgner, F. X. Kärtner, J. G. Fujimoto

    Research output: Contribution to journalConference article

    Abstract

    Using state of the art laser technology, third generation ophthalmologic optical coherence tomography (OCT) has been developed which enables ultrahigh resolution, non-invasive in vivo imaging of retinal morphology with an unprecedented axial resolution of 3 μm. This represents a quantum leap in performance over the 10-15 μm resolution currently available in ophthalmic OCT systems and, to our knowledge, is the highest resolution in vivo ophthalmologic imaging achieved to date. This resolution enables optical biopsy, i.e. the in vivo visualization of intraretinal architectural morphology which had previously only been possible with histopathology. Image processing and segmentation techniques are demonstrated for automatic identification and quantification of retinal morphology. Ultrahigh resolution ophthalmic OCT has the potential to enhance the sensitivity and specificity for early diagnosis of several ocular diseases, e.g. glaucoma, which requires precise imaging and measurement of retinal nerve fiber layer thickness, as well as improve monitoring of disease progression and efficacy of therapy.

    Original languageEnglish (US)
    Pages (from-to)183-187
    Number of pages5
    JournalProceedings of SPIE - The International Society for Optical Engineering
    Volume4251
    DOIs
    StatePublished - 2001
    EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications V - San Jose, CA, United States
    Duration: Jan 23 2001Jan 24 2001

    Keywords

    • Ophthalmology
    • Optical biopsy
    • Optical coherence tomography
    • Retinal imaging
    • Ti:AlO laser

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

    Fingerprint Dive into the research topics of 'In vivo optical biopsy of the human retina using optical coherence tomography'. Together they form a unique fingerprint.

  • Cite this

    Drexler, W., Ghanta, R. K., Schuman, J. S., Ko, T., Morgner, U., Kärtner, F. X., & Fujimoto, J. G. (2001). In vivo optical biopsy of the human retina using optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering, 4251, 183-187. https://doi.org/10.1117/12.427892