In vivo oral insulin delivery via covalent organic frameworks

Farah Benyettou; Nawel Kaddour; Thirumurugan Prakasam; Gobinda Das; Sudhir Kumar Sharma; Sneha Ann Thomas; Fadia Bekhti-Sari; Jamie Whelan; Mohammed A. Alkhalifah; Mostafa Khair; Hassan Traboulsi; Renu Pasricha; Ramesh Jagannathan; Nassima Mokhtari-Soulimane; Felipe Gándara; Ali Trabolsi

doi:10.1039/d0sc05328g

In vivo oral insulin delivery via covalent organic frameworks

Farah Benyettou, Nawel Kaddour, Thirumurugan Prakasam, Gobinda Das, Sudhir Kumar Sharma, Sneha Ann Thomas, Fadia Bekhti-Sari, Jamie Whelan, Mohammed A. Alkhalifah, Mostafa Khair, Hassan Traboulsi, Renu Pasricha, Ramesh Jagannathan, Nassima Mokhtari-Soulimane, Felipe Gándara, Ali Trabolsi

Research output: Contribution to journal › Article › peer-review

Abstract

With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.

Original language	English (US)
Pages (from-to)	6037-6047
Number of pages	11
Journal	Chemical Science
Volume	12
Issue number	17
DOIs	https://doi.org/10.1039/d0sc05328g
State	Published - May 7 2021

ASJC Scopus subject areas

General Chemistry

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10.1039/d0sc05328g

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Benyettou, F., Kaddour, N., Prakasam, T., Das, G., Sharma, S. K., Thomas, S. A., Bekhti-Sari, F., Whelan, J., Alkhalifah, M. A., Khair, M., Traboulsi, H., Pasricha, R., Jagannathan, R., Mokhtari-Soulimane, N., Gándara, F., & Trabolsi, A. (2021). In vivo oral insulin delivery via covalent organic frameworks. Chemical Science, 12(17), 6037-6047. https://doi.org/10.1039/d0sc05328g

Benyettou, F, Kaddour, N, Prakasam, T, Das, G, Sharma, SK, Thomas, SA, Bekhti-Sari, F, Whelan, J, Alkhalifah, MA, Khair, M, Traboulsi, H, Pasricha, R, Jagannathan, R, Mokhtari-Soulimane, N, Gándara, F & Trabolsi, A 2021, 'In vivo oral insulin delivery via covalent organic frameworks', Chemical Science, vol. 12, no. 17, pp. 6037-6047. https://doi.org/10.1039/d0sc05328g

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abstract = "With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.",

author = "Farah Benyettou and Nawel Kaddour and Thirumurugan Prakasam and Gobinda Das and Sharma, {Sudhir Kumar} and Thomas, {Sneha Ann} and Fadia Bekhti-Sari and Jamie Whelan and Alkhalifah, {Mohammed A.} and Mostafa Khair and Hassan Traboulsi and Renu Pasricha and Ramesh Jagannathan and Nassima Mokhtari-Soulimane and Felipe G{\'a}ndara and Ali Trabolsi",

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AU - Benyettou, Farah

AU - Kaddour, Nawel

AU - Prakasam, Thirumurugan

AU - Das, Gobinda

AU - Sharma, Sudhir Kumar

AU - Thomas, Sneha Ann

AU - Bekhti-Sari, Fadia

AU - Whelan, Jamie

AU - Alkhalifah, Mohammed A.

AU - Khair, Mostafa

AU - Traboulsi, Hassan

AU - Pasricha, Renu

AU - Jagannathan, Ramesh

AU - Mokhtari-Soulimane, Nassima

AU - Gándara, Felipe

AU - Trabolsi, Ali

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Y1 - 2021/5/7

N2 - With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.

AB - With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.

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In vivo oral insulin delivery via covalent organic frameworks

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