In vivo oral insulin delivery via covalent organic frameworks

Farah Benyettou, Nawel Kaddour, Thirumurugan Prakasam, Gobinda Das, Sudhir Kumar Sharma, Sneha Ann Thomas, Fadia Bekhti-Sari, Jamie Whelan, Mohammed A. Alkhalifah, Mostafa Khair, Hassan Traboulsi, Renu Pasricha, Ramesh Jagannathan, Nassima Mokhtari-Soulimane, Felipe Gándara, Ali Trabolsi

Research output: Contribution to journalArticlepeer-review


With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.

Original languageEnglish (US)
Pages (from-to)6037-6047
Number of pages11
JournalChemical Science
Issue number17
StatePublished - May 7 2021

ASJC Scopus subject areas

  • General Chemistry


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