In Vivo Photopharmacology

Katharina Hüll, Johannes Morstein, Dirk Trauner

Research output: Contribution to journalReview article

Abstract

Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have become established, they have been applied to a wide range of biological targets. These include transmembrane proteins (ion channels, transporters, G protein-coupled receptors, receptor-linked enzymes), soluble proteins (kinases, proteases, factors involved in epigenetic regulation), lipid membranes, and nucleic acids. In this review, we provide an overview of photopharmacology using synthetic switches that have been applied in vivo, i.e., in living cells and organisms. We discuss the scope and limitations of this approach to study biological function and the challenges it faces in translational medicine. The relationships between synthetic photoswitches, natural chromophores used in optogenetics, and caged ligands are addressed.

Original languageEnglish (US)
Pages (from-to)10710-10747
Number of pages38
JournalChemical reviews
Volume118
Issue number21
DOIs
StatePublished - Nov 14 2018

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Hüll, K., Morstein, J., & Trauner, D. (2018). In Vivo Photopharmacology. Chemical reviews, 118(21), 10710-10747. https://doi.org/10.1021/acs.chemrev.8b00037