Inactivation of semicircular canals causes adaptive increases in otolith-driven tilt responses

Dora E. Angelaki, Shawn D. Newlands, J. David Dickman

Research output: Contribution to journalArticle

Abstract

Growing experimental and theoretical evidence suggests a functional synergy in the processing of otolith and semicircular canal signals for the generation of the vestibulo-ocular reflexes (VORs). In this study we have further tested this functional interaction by quantifying the adaptive changes in the otolith-ocular system during both rotational and translational movements after surgical inactivation of the semicircular canals. For 0.1-0.5 Hz (stimuli for which there is no recovery of responses from the plugged canals), pitch and roll VOR gains recovered during earth-horizontal (but not earth-vertical) axis rotations. Corresponding changes were also observed in eye movements elicited by translational motion (0.1-5 Hz). Specifically, torsional eye movements increased during lateral motion, whereas vertical eye movements increased during fore-aft motion. The findings indicate that otolith signals can be adapted according to a compromised strategy that leads to improved gaze stabilization during motion. Because canal-plugged animals permanently lose the ability to discriminate gravitoinertial accelerations, adapted animals can use the presence of gravity through otolith-driven tilt responses to assist gaze stabilization during earth-horizontal axis rotations.

Original languageEnglish (US)
Pages (from-to)1635-1640
Number of pages6
JournalJournal of neurophysiology
Volume87
Issue number3
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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