Incorporation of Macromolecules into α-Lactose Monohydrate Crystals

Alexander G. Shtukenberg, Kelly Tripathi, Remi Ketchum, Jenny Jaehee Jeon, Ahmed Sanda, Bart Kahr

Research output: Contribution to journalArticlepeer-review


It had been discovered that crystals of α-lactose monohydrate can occlude and give kinetic stability to various proteins, an unexpected observation suggesting a process for storing protein vaccines and biopharmaceuticals at room temperature. The growth of α-lactose monohydrate with proteins is analyzed herein, emphasizing segregation coefficients, the relationships between protein incorporation and buffer composition, temperature, growth rate, and mass transport. Detailed examination of bovine serum albumin is supported by data for eight other proteins. A search for other crystals with lactose-like inclusivity of macromolecular guests is also reported.

Original languageEnglish (US)
Pages (from-to)4589-4598
Number of pages10
JournalCrystal Growth and Design
Issue number8
StatePublished - Aug 3 2016

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics


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