Increased Saliva Cotinine Concentrations in Smokers During Rapid Weight Loss

Raymond Niaura, Matthew M. Clark, Michael A. Raciti, Vincent Pera, David B. Abrams

Research output: Contribution to journalArticlepeer-review


Although the effect of smoking cessation on weight gain is well-documented, little is known about the effect of weight loss on smoking. We examined the association between saliva cotinine levels and weight loss in a group of 9 obese female smokers during participation in a protein-sparing modified fast (Optifast). For the first 3 months of treatment, subjects consumed only the protein-sparing supplement; for the next 3 months, food was gradually reintroduced. Body mass index and saliva cotinine concentration were assessed at study entry and at 3 and 6 months. A significant weight loss was noted at 3 and 6 months, yet the cotinine level increased significantly over this time. It is unclear whether the cotinine increase is due to metabolic changes or an actual increase in nicotine intake. The results suggest that smoking-related health risks may increase during periods of significant weight loss.

Original languageEnglish (US)
Pages (from-to)985-987
Number of pages3
JournalJournal of consulting and clinical psychology
Issue number6
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Increased Saliva Cotinine Concentrations in Smokers During Rapid Weight Loss'. Together they form a unique fingerprint.

Cite this