Increased tyrosine hydroxylase immunoreactivity in the rat cortex following prenatal cocaine exposure

H. M. Akbari, E. C. Azmitia

Research output: Contribution to journalArticle

Abstract

Cocaine has been found to be a neurobehavioral teratogen in both animals and humans. In this study the effects of cocaine on the developing catecholamine systems were examined. Rats were treated gestationally with cocaine (40 mg/kg s.c.) or saline from gestational day 13 until parturition. On postnatal day 28, tyrosine hydroxylase immunocytochemistry was performed. Increases in catecholamine fiber densities were observed in the hippocampus, anterior cingulate cortex, and parietal cortex in cocaine-treated animals. These findings may explain some of the behavioral alterations seen following prenatal cocaine exposure.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalDevelopmental Brain Research
Volume66
Issue number2
DOIs
StatePublished - Apr 24 1992

Keywords

  • Catecholamine
  • Cocaine
  • Hyperinnervation
  • Immunocytochemistry
  • Neuronal development
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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