Increased tyrosine hydroxylase immunoreactivity in the rat cortex following prenatal cocaine exposure

H. M. Akbari; E. C. Azmitia

doi:10.1016/0165-3806(92)90093-C

Increased tyrosine hydroxylase immunoreactivity in the rat cortex following prenatal cocaine exposure

H. M. Akbari, E. C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Cocaine has been found to be a neurobehavioral teratogen in both animals and humans. In this study the effects of cocaine on the developing catecholamine systems were examined. Rats were treated gestationally with cocaine (40 mg/kg s.c.) or saline from gestational day 13 until parturition. On postnatal day 28, tyrosine hydroxylase immunocytochemistry was performed. Increases in catecholamine fiber densities were observed in the hippocampus, anterior cingulate cortex, and parietal cortex in cocaine-treated animals. These findings may explain some of the behavioral alterations seen following prenatal cocaine exposure.

Original language	English (US)
Pages (from-to)	277-281
Number of pages	5
Journal	Developmental Brain Research
Volume	66
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(92)90093-C
State	Published - Apr 24 1992

Keywords

Catecholamine
Cocaine
Hyperinnervation
Immunocytochemistry
Neuronal development
Tyrosine hydroxylase

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(92)90093-C

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title = "Increased tyrosine hydroxylase immunoreactivity in the rat cortex following prenatal cocaine exposure",

abstract = "Cocaine has been found to be a neurobehavioral teratogen in both animals and humans. In this study the effects of cocaine on the developing catecholamine systems were examined. Rats were treated gestationally with cocaine (40 mg/kg s.c.) or saline from gestational day 13 until parturition. On postnatal day 28, tyrosine hydroxylase immunocytochemistry was performed. Increases in catecholamine fiber densities were observed in the hippocampus, anterior cingulate cortex, and parietal cortex in cocaine-treated animals. These findings may explain some of the behavioral alterations seen following prenatal cocaine exposure.",

keywords = "Catecholamine, Cocaine, Hyperinnervation, Immunocytochemistry, Neuronal development, Tyrosine hydroxylase",

author = "Akbari, {H. M.} and Azmitia, {E. C.}",

note = "Funding Information: Research supported by NIDA Contract 271-90-7403. The authors wish to thank Patrick Gannon for photographic assistance.",

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AU - Akbari, H. M.

AU - Azmitia, E. C.

N1 - Funding Information: Research supported by NIDA Contract 271-90-7403. The authors wish to thank Patrick Gannon for photographic assistance.

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N2 - Cocaine has been found to be a neurobehavioral teratogen in both animals and humans. In this study the effects of cocaine on the developing catecholamine systems were examined. Rats were treated gestationally with cocaine (40 mg/kg s.c.) or saline from gestational day 13 until parturition. On postnatal day 28, tyrosine hydroxylase immunocytochemistry was performed. Increases in catecholamine fiber densities were observed in the hippocampus, anterior cingulate cortex, and parietal cortex in cocaine-treated animals. These findings may explain some of the behavioral alterations seen following prenatal cocaine exposure.

AB - Cocaine has been found to be a neurobehavioral teratogen in both animals and humans. In this study the effects of cocaine on the developing catecholamine systems were examined. Rats were treated gestationally with cocaine (40 mg/kg s.c.) or saline from gestational day 13 until parturition. On postnatal day 28, tyrosine hydroxylase immunocytochemistry was performed. Increases in catecholamine fiber densities were observed in the hippocampus, anterior cingulate cortex, and parietal cortex in cocaine-treated animals. These findings may explain some of the behavioral alterations seen following prenatal cocaine exposure.

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KW - Cocaine

KW - Hyperinnervation

KW - Immunocytochemistry

KW - Neuronal development

KW - Tyrosine hydroxylase

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Increased tyrosine hydroxylase immunoreactivity in the rat cortex following prenatal cocaine exposure

Abstract

Keywords

ASJC Scopus subject areas

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