Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials

Marya Viorst Gwadz, Pablo Colon, Amanda S. Ritchie, Noelle R. Leonard, Charles M. Cleland, Marion Riedel, Deshannon Bowens, Angela D. Banfield, Patricia Chang, Robert Quiles, Donna Mildvan

Research output: Contribution to journalReview articlepeer-review


Persons living with HIV/AIDS (PLHA) of color are under-represented in AIDS clinical trials (ACTs), which may limit the generalizability of research findings and denies many individuals access to high levels of care and new treatments available through ACTs. Disproportionately low rates of recruitment in health care settings and by providers are a major barrier to ACTs for this group. Moreover, PLHA of color are more likely than their white peers to decline to participate, mainly due to fear and mistrust (although willingness is also high), negative social norms about ACTs, and difficulty navigating the unfamiliar ACT system. We describe a small number of successful behavioral and structural interventions to increase the participation of PLHA of color in screening for and enrollment into ACTs. HIV care settings, clinical trials sites, and trial sponsors are uniquely positioned to develop procedures, supports, and trials to increase the proportion of PLHA of color in ACTs.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalCurrent HIV/AIDS Reports
Issue number4
StatePublished - Nov 2010


  • Access
  • African-American
  • Clinical trials
  • Latino
  • Racial/ethnic disparities

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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