@inproceedings{395f7d3dce5d436aaaac0b4e6a9d2f32,
title = "Increasing the detection sensitivity for dnamorpholino hybridization in sub-nanomolar regime by enhancing the surface ion conductance of PEDOT: PSS membrane in a microchannel",
abstract = "In this study, we demonstrate that increasing the surface conductance of the ion-selective membrane can achieve higher Ion concentration polarization (ICP) of DNA. The surface conductance of the conductive polymer membrane, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), can be enhanced either by increasing its thickness or surface charge. Using a ∼6 μm thick PEDOT:PSS membrane with a highly negative surface charge, we could achieve a concentration increase of DNA by 6 orders of magnitude from an initial concentration of 100 fM within 10 min., and detect a DNA target concentration at 10 pM within 15 min. via surface hybridization on the morpholinos (MO).",
keywords = "DNA hybridization, Ion concentration polarization, Morpholinos (MO), PEDOT:PSS",
author = "X. Wei and Q. Zhang and Song, {Y. A.}",
year = "2016",
language = "English (US)",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "896--897",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
}