TY - JOUR
T1 - Induced pluripotent stem (iPS) cells
T2 - A new source for cell-based therapeutics?
AU - De Lázaro, Irene
AU - Yilmazer, Açelya
AU - Kostarelos, Kostas
PY - 2014/7/10
Y1 - 2014/7/10
N2 - The generation of induced pluripotent stem (iPS) cells from somatic cells by the ectopic expression of defined transcription factors has provided the regenerative medicine field with a new tool for cell replacement strategies. The advantages that these pluripotent cells can offer in comparison to other sources of stem cells include the generation of patient-derived cells and the lack of embryonic tissue while maintaining a versatile differentiation potential. The promise of iPS cell derivatives for therapeutic applications is encouraging albeit very early in development, with the first clinical study currently ongoing in Japan. Many challenges are yet to be circumvented before this technology can be clinically translated widely though. The delivery and expression of the reprogramming factors, the genomic instability, epigenetic memory and impact of cell propagation in culture are only some of the concerns. This article aims to critically discuss the potential of iPS cells as a new source of cell therapeutics.
AB - The generation of induced pluripotent stem (iPS) cells from somatic cells by the ectopic expression of defined transcription factors has provided the regenerative medicine field with a new tool for cell replacement strategies. The advantages that these pluripotent cells can offer in comparison to other sources of stem cells include the generation of patient-derived cells and the lack of embryonic tissue while maintaining a versatile differentiation potential. The promise of iPS cell derivatives for therapeutic applications is encouraging albeit very early in development, with the first clinical study currently ongoing in Japan. Many challenges are yet to be circumvented before this technology can be clinically translated widely though. The delivery and expression of the reprogramming factors, the genomic instability, epigenetic memory and impact of cell propagation in culture are only some of the concerns. This article aims to critically discuss the potential of iPS cells as a new source of cell therapeutics.
KW - Cell replacement therapy
KW - Pluripotency
KW - Regenerative medicine
KW - Reprogramming
UR - http://www.scopus.com/inward/record.url?scp=84900453177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900453177&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2014.04.011
DO - 10.1016/j.jconrel.2014.04.011
M3 - Review article
C2 - 24746625
AN - SCOPUS:84900453177
SN - 0168-3659
VL - 185
SP - 37
EP - 44
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -