Induction and Specification of Neural Crest Cells: Extracellular Signals and Transcriptional Switches

Chang Joon Bae; Jean Pierre Saint-Jeannet

doi:10.1016/B978-0-12-401730-6.00002-8

Induction and Specification of Neural Crest Cells: Extracellular Signals and Transcriptional Switches

Chang Joon Bae, Jean Pierre Saint-Jeannet

Molecular Pathobiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The neural crest is a multipotent population of migratory cells unique to the vertebrate embryo. Neural crest cells form at the neural plate border during gastrulation and, around the time of neural tube closure, leave the neuroepithelium to produce a diverse array of cell types, contributing to multiple organ systems. Neural crest cells are generated through a sequence of events orchestrated by the modulation of several signaling pathways and the activation of a complex network of transcription factors. Here, we review recent advances in the characterization of the molecular players directing neural crest induction and specification, comparing data from different model organisms.

Original language	English (US)
Title of host publication	Neural Crest Cells
Subtitle of host publication	Evolution, Development and Disease
Publisher	Elsevier Inc.
Pages	27-49
Number of pages	23
ISBN (Print)	9780124017306
DOIs	https://doi.org/10.1016/B978-0-12-401730-6.00002-8
State	Published - 2014

Keywords

Bmp
Fgf
Gene regulatory network
Neural crest
Wnt

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-12-401730-6.00002-8

Cite this

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title = "Induction and Specification of Neural Crest Cells: Extracellular Signals and Transcriptional Switches",

abstract = "The neural crest is a multipotent population of migratory cells unique to the vertebrate embryo. Neural crest cells form at the neural plate border during gastrulation and, around the time of neural tube closure, leave the neuroepithelium to produce a diverse array of cell types, contributing to multiple organ systems. Neural crest cells are generated through a sequence of events orchestrated by the modulation of several signaling pathways and the activation of a complex network of transcription factors. Here, we review recent advances in the characterization of the molecular players directing neural crest induction and specification, comparing data from different model organisms.",

keywords = "Bmp, Fgf, Gene regulatory network, Neural crest, Wnt",

author = "Bae, {Chang Joon} and Saint-Jeannet, {Jean Pierre}",

note = "Funding Information: We thank Dr. Jane McCutcheon for comments on the manuscript. We would like to apologize to colleagues whose work is not cited here, due to space limitations. Work in J-P S-J{\textquoteright}s lab is supported by a grant from the National Institutes of Health (RO1-DE014212).",

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T2 - Extracellular Signals and Transcriptional Switches

AU - Bae, Chang Joon

AU - Saint-Jeannet, Jean Pierre

N1 - Funding Information: We thank Dr. Jane McCutcheon for comments on the manuscript. We would like to apologize to colleagues whose work is not cited here, due to space limitations. Work in J-P S-J’s lab is supported by a grant from the National Institutes of Health (RO1-DE014212).

PY - 2014

Y1 - 2014

N2 - The neural crest is a multipotent population of migratory cells unique to the vertebrate embryo. Neural crest cells form at the neural plate border during gastrulation and, around the time of neural tube closure, leave the neuroepithelium to produce a diverse array of cell types, contributing to multiple organ systems. Neural crest cells are generated through a sequence of events orchestrated by the modulation of several signaling pathways and the activation of a complex network of transcription factors. Here, we review recent advances in the characterization of the molecular players directing neural crest induction and specification, comparing data from different model organisms.

AB - The neural crest is a multipotent population of migratory cells unique to the vertebrate embryo. Neural crest cells form at the neural plate border during gastrulation and, around the time of neural tube closure, leave the neuroepithelium to produce a diverse array of cell types, contributing to multiple organ systems. Neural crest cells are generated through a sequence of events orchestrated by the modulation of several signaling pathways and the activation of a complex network of transcription factors. Here, we review recent advances in the characterization of the molecular players directing neural crest induction and specification, comparing data from different model organisms.

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PB - Elsevier Inc.

ER -

Induction and Specification of Neural Crest Cells: Extracellular Signals and Transcriptional Switches

Abstract

Keywords

ASJC Scopus subject areas

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