Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging

John H. Gilmore; Guido Gerig; Barbara Specter; H. Cecil Charles; Joseph S. Wilber; Barbara S. Hertzberg; Mark A. Kliewer

doi:10.1016/S0301-5629(01)00400-8

Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging

John H. Gilmore, Guido Gerig, Barbara Specter, H. Cecil Charles, Joseph S. Wilber, Barbara S. Hertzberg, Mark A. Kliewer

Research output: Contribution to journal › Article

Abstract

Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the 'gold standard' of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.

Original language	English (US)
Pages (from-to)	1143-1146
Number of pages	4
Journal	Ultrasound in Medicine and Biology
Volume	27
Issue number	8
DOIs	https://doi.org/10.1016/S0301-5629(01)00400-8
State	Published - 2001

Keywords

Computer-assisted image analysis
Lateral ventricle
Magnetic resonance imaging
Neurodevelopmental disorders
Premature infants
Three-dimensional ultrasound

ASJC Scopus subject areas

Biophysics
Radiological and Ultrasound Technology
Acoustics and Ultrasonics

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10.1016/S0301-5629(01)00400-8

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Gilmore, J. H., Gerig, G., Specter, B., Charles, H. C., Wilber, J. S., Hertzberg, B. S., & Kliewer, M. A. (2001). Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging. Ultrasound in Medicine and Biology, 27(8), 1143-1146. https://doi.org/10.1016/S0301-5629(01)00400-8

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abstract = "Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the 'gold standard' of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.",

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AU - Gerig, Guido

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AU - Charles, H. Cecil

AU - Wilber, Joseph S.

AU - Hertzberg, Barbara S.

AU - Kliewer, Mark A.

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N2 - Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the 'gold standard' of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.

AB - Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the 'gold standard' of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.

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KW - Neurodevelopmental disorders

KW - Premature infants

KW - Three-dimensional ultrasound

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