TY - JOUR
T1 - Infant cerebral ventricle volume
T2 - a comparison of 3-D ultrasound and magnetic resonance imaging
AU - Gilmore, John H.
AU - Gerig, Guido
AU - Specter, Barbara
AU - Charles, H. Cecil
AU - Wilber, Joseph S.
AU - Hertzberg, Barbara S.
AU - Kliewer, Mark A.
N1 - Funding Information:
This study was supported by the Theodore and Vada Stanley Foundation and NIMH Center Grant MH 33127. The authors thank Kwanna Williamson, R.N., for her excellent work on this study and Mauricio Castillo, M.D., for his clinical interpretations of the MRIs.
PY - 2001
Y1 - 2001
N2 - Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the 'gold standard' of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.
AB - Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the 'gold standard' of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.
KW - Computer-assisted image analysis
KW - Lateral ventricle
KW - Magnetic resonance imaging
KW - Neurodevelopmental disorders
KW - Premature infants
KW - Three-dimensional ultrasound
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U2 - 10.1016/S0301-5629(01)00400-8
DO - 10.1016/S0301-5629(01)00400-8
M3 - Article
C2 - 11527602
AN - SCOPUS:0034876409
VL - 27
SP - 1143
EP - 1146
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 8
ER -