Influence of blood vessels on the measurement of hemoglobin oxygenation as determined by time-resolved reflectance spectroscopy

H Liu, Britton Chance, Andreas Hielscher, Steven L. Jacques, Frank Tittel

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We report the development of a heterogeneous resin-tube model to study the influence of blood vessels on the apparent absorption of the system, μa(sys), using a time-resolved technique. The experimental results show that μa(sys) depends on the absorption inside the tubes, μa(tube), tube diameters, and tube-to-sample volume ratios. A mathematical expression relating μa(sys) and μa(tube) is derived based on the experimental results and is verified by time-resolved Monte Carlo simulations for heterogeneous models. This analytical formula predicts that the apparent absorption coefficient measured on a biological organ is a volume-weighted sum of the absorption coefficients of different absorbing components. We present some apparent absorption coefficients measured in vivo in animals and humans and discuss improved algorithms that calculate the hemoglobin saturation by including background-tissue absorption and blood vessel distribution.

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