Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

Hang Liu, Sanjairaj Vijayavenkataraman, Dandan Wang, Linzhi Jing, Jie Sun, Kai He

Research output: Contribution to journalArticle

Abstract

One of the important constituents in tissue engineering is scaffold, which provides structural support and suitable microenvironment for the cell attachment, growth and proliferation. To fabricate micro/nano structures for soft tissue repair and three-dimensional (3D) cell culture, the key is to improve fibre-based scaffold fabrication. Electrohy-drodynamic (EHD) jetting is capable of producing and orientating submicron fibres for 3D scaffold fabrication. In this work, an EHD-jetting system was developed to explore the relationship between vital processing parameters and fibre characteristics. In this study, polycaprolactone (PCL) solution prepared by dissolving PCL pellets in acetic acid was used to fabricate the scaffolds. The influence of voltage, motorized stage speed, solution feed rate, and solution concen-tration on fibre characteristics and scaffold pattern were studied. Morphology of the EHD-jetted PCL fibres and scaf-folds were analysed using optical microscope images and scanning electron microscope (SEM) images. Multi-layer scaffolds with the varied coiled pattern were fabricated and analysed. Cell attachment and proliferation have to be in-vestigated in the future by further cell culture studies on these multi-layer coiled scaffolds.

Original languageEnglish (US)
Pages (from-to)72-82
Number of pages11
JournalInternational Journal of Bioprinting
Volume3
Issue number1
DOIs
StatePublished - 2017

Keywords

  • 3D bioprinting
  • Electrohydrodynamic jetting
  • Polycaprolactone scaffolds
  • Soft-tissue
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Materials Science (miscellaneous)
  • Industrial and Manufacturing Engineering

Fingerprint Dive into the research topics of 'Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds'. Together they form a unique fingerprint.

  • Cite this