TY - JOUR
T1 - Influence of estrogen deficiency on bone around osseointegrated dental implants
T2 - An experimental study in the rat jaw model
AU - Giro, Gabriela
AU - Coelho, Paulo G.
AU - Sales-Pessoa, Roberto
AU - Rodrigues Pereira, Rosa Maria
AU - Kawai, Toshihisa
AU - Perez Orrico, Silvana Regina
N1 - Funding Information:
Dr Giro was supported by the São Paulo State Research Support Foundation (FAPESP, grant 2005/03737-8 ) and the Coordination for Improvement of Higher Education Students (CAPES, PDEEE program). This study was also supported by National Institutes of Health grants DE-018499 and DE-019917 from the National Institute of Dental and Craniofacial Research. The authors gratefully acknowledge SIN—Sistema de Implante for supplying the implants used in this study.
PY - 2011/7
Y1 - 2011/7
N2 - Purpose: The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model. Materials and Methods: This study used 16 female rats that had the first molars bilaterally extracted and were allowed to heal for 30 days before implant placement. Sixty days after implant placement, the animals were randomly subjected to sham surgery or ovariectomy (OVX). The animals were euthanized 90 days after OVX. Bone-to-implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers, and cells positive for tartrate-resistant acid phosphatase were assessed for the 2 groups. Results: The results showed that OVX group presented a decrease of systemic bone density, alterations in bone turnover markers, and an increase of cells positive for tartrate-resistant acid phosphatase compared with the sham-surgery group. However, no difference relative to bone-to-implant contact and bone area fraction occupancy was observed between groups. Conclusions: The findings of this study demonstrate that estrogen deficiency may not be considered a risk factor for osseointegrated implant failure in jaw bone.
AB - Purpose: The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model. Materials and Methods: This study used 16 female rats that had the first molars bilaterally extracted and were allowed to heal for 30 days before implant placement. Sixty days after implant placement, the animals were randomly subjected to sham surgery or ovariectomy (OVX). The animals were euthanized 90 days after OVX. Bone-to-implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers, and cells positive for tartrate-resistant acid phosphatase were assessed for the 2 groups. Results: The results showed that OVX group presented a decrease of systemic bone density, alterations in bone turnover markers, and an increase of cells positive for tartrate-resistant acid phosphatase compared with the sham-surgery group. However, no difference relative to bone-to-implant contact and bone area fraction occupancy was observed between groups. Conclusions: The findings of this study demonstrate that estrogen deficiency may not be considered a risk factor for osseointegrated implant failure in jaw bone.
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U2 - 10.1016/j.joms.2011.01.028
DO - 10.1016/j.joms.2011.01.028
M3 - Article
C2 - 21530046
AN - SCOPUS:79959377191
SN - 0278-2391
VL - 69
SP - 1911
EP - 1918
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 7
ER -