Abstract
Background: Interleukin 10 (IL-10) is a multifunctional cytokine produced by macrophages, monocytes, and T-helper cells. Two polymorphisms at positions -592 and -1082 have been associated with HIV susceptibility. However, their associations with susceptibility to HIV and its co-infections among intravenous drug users (IDUs) are largely unknown. Methods: A total of 345 IDUs were recruited. Of the 173 HIV negative IDUs, 20 were classified as highly exposed HIV seronegative subjects (HESNs). A control group consisted of 496 blood donors; all HIV, HCV, and HBV negative. The IL-10-592C/A and -1082A/G were determined using TaqMan allelic discrimination assay. Results: Of the IDUs, 50% were HIV positive, 89% HCV positive, 67% HBV positive and 41% had triple infection. IL-10-592C allele and -1082A allele were the most common and the -1082AG/-592CC was the most common genotype pair. All HESNs exhibited -1082A allele as compared to 81.4% of the HIV positive IDUs and 79% of donors (p= 0.029 and p= 0.019, respectively). None of HESNs had GG/CC genotype pair compared with 18.6% of HIV positive IDUs and 21.0% of donors (p= 0.029 and p= 0.019, respectively). The possession of -592AC and genotype pair AG/AC were associated with the decreased odds of HBV infection (OR. = 0.28; 95% CI 0.09-0.87; p= 0.028 and OR. = 0.19; 95% CI 0.06-0.61; p= 0.052, respectively). Conclusions: The presence of low producing IL-10-1082A and -592A alleles and their containing genetic variants protect highly exposed IDUs against acquisition of HIV and HBV infections.
Original language | English (US) |
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Pages (from-to) | 175-180 |
Number of pages | 6 |
Journal | Infection, Genetics and Evolution |
Volume | 30 |
DOIs | |
State | Published - Mar 1 2015 |
Keywords
- Co-infection
- Genetic factors
- HIV susceptibility
- IDU
- IL-10
- Inflammation
ASJC Scopus subject areas
- Microbiology
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Genetics
- Microbiology (medical)
- Infectious Diseases