Influence of psychological factors on risk of temporomandibular disorders

G. D. Slade, L. Diatchenko, K. Bhalang, A. Sigurdsson, R. B. Fillingim, I. Belfer, M. B. Max, D. Goldman, W. Maixner

Research output: Contribution to journalArticlepeer-review


Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encoding catechol-O-methyltransferase (COMT). We undertook a prospective cohort study of healthy female volunteers aged 18-34 yrs. At baseline, participants were genotyped, they completed psychological questionnaires, and underwent quantitative sensory testing to determine pain sensitivity. We followed 171 participants for up to three years, and 8.8% of them were diagnosed with first-onset TMD. Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05). However, the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype. Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk.

Original languageEnglish (US)
Pages (from-to)1120-1125
Number of pages6
JournalJournal of dental research
Issue number11
StatePublished - Nov 2007


  • Catechol O-methyltransferase
  • Cohort studies
  • Genetics
  • Psychology
  • Temporomandibular joint disorders

ASJC Scopus subject areas

  • General Dentistry


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