Influence of the carcinogen 4-aminobiphenyl on DNA conformation

S. Broyde, B. E. Hingerty, A. R. Srinivasan

Research output: Contribution to journalArticle

Abstract

The conformation of the deoxydinucleoside monophosphate dCpdG modified by the carcinogen 4-aminobiphenyl has been elucidated by minimized semi-empirical potential energy calculations. The most important conformers relevant to A or B and Z helices are shown, and the structures of carcinogen-modified polymers, obtained from computer-generated models that incorporate the dimer conformations, are presented. Forms with carcinogen-hase stacking and with base-base stacking are found, for both A-B type heilces and Z-type helices. In random sequence DNA, the most favored state places the carcinogen at the A or B helix exterior, in the large groove, where it causes no distortion. In this position it might escape repair till a round of replication. At the replication fork, where the DNA is unwound, a low energy carcinogen-base stacked state, easily achieved by rotation primarily about the C5'-05' bond, could occur. A mutagenic outcome resulting from this conformation might be envisioned.

Original languageEnglish (US)
Pages (from-to)719-725
Number of pages7
JournalCarcinogenesis
Volume6
Issue number5
DOIs
StatePublished - May 1985

ASJC Scopus subject areas

  • Cancer Research

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