Influence of the Ionic Environment on the Conformation of Aspartic Acid and Possible Relevance to Its Neurotransmitter Action

Gennaro Esposito; Andrea Motta; Piero A. Temussi

doi:10.1111/j.1471-4159.1983.tb08071.x

Influence of the Ionic Environment on the Conformation of Aspartic Acid and Possible Relevance to Its Neurotransmitter Action

Gennaro Esposito, Andrea Motta, Piero A. Temussi

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The conformational changes of aspartic acid, a possible neurotransmitter, induced by increasing ionic strength were investigated by means of NMR spectros‐copy. The effects of Li, Na, K, and Cs chlorides in basic and neutral conditions were characterized. The effects of the presence of both Ca²⁺ and Na⁺ or K⁺ were also examined. The results always showed a relative stabilization of the two conformers with gauche carboxylates at the expense of the anticonformer. The significant quantitative difference found between Na⁺ and K⁺ in basic solutions, as well as between calcium‐free and calcium‐containing solutions, may bear some relevance for the role of aspartate as a CNS neurotransmitter.

Original language	English (US)
Pages (from-to)	903-907
Number of pages	5
Journal	Journal of Neurochemistry
Volume	40
Issue number	4
DOIs	https://doi.org/10.1111/j.1471-4159.1983.tb08071.x
State	Published - Apr 1983

Keywords

Alkaline chlorides
Aspartate
Conformation
Neurotransmitter conformation.

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1983.tb08071.x

Cite this

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abstract = "The conformational changes of aspartic acid, a possible neurotransmitter, induced by increasing ionic strength were investigated by means of NMR spectros‐copy. The effects of Li, Na, K, and Cs chlorides in basic and neutral conditions were characterized. The effects of the presence of both Ca2+ and Na+ or K+ were also examined. The results always showed a relative stabilization of the two conformers with gauche carboxylates at the expense of the anticonformer. The significant quantitative difference found between Na+ and K+ in basic solutions, as well as between calcium‐free and calcium‐containing solutions, may bear some relevance for the role of aspartate as a CNS neurotransmitter.",

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AU - Motta, Andrea

AU - Temussi, Piero A.

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AB - The conformational changes of aspartic acid, a possible neurotransmitter, induced by increasing ionic strength were investigated by means of NMR spectros‐copy. The effects of Li, Na, K, and Cs chlorides in basic and neutral conditions were characterized. The effects of the presence of both Ca2+ and Na+ or K+ were also examined. The results always showed a relative stabilization of the two conformers with gauche carboxylates at the expense of the anticonformer. The significant quantitative difference found between Na+ and K+ in basic solutions, as well as between calcium‐free and calcium‐containing solutions, may bear some relevance for the role of aspartate as a CNS neurotransmitter.

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Influence of the Ionic Environment on the Conformation of Aspartic Acid and Possible Relevance to Its Neurotransmitter Action

Abstract

Keywords

ASJC Scopus subject areas

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