The conformational changes of aspartic acid, a possible neurotransmitter, induced by increasing ionic strength were investigated by means of NMR spectros‐copy. The effects of Li, Na, K, and Cs chlorides in basic and neutral conditions were characterized. The effects of the presence of both Ca2+ and Na+ or K+ were also examined. The results always showed a relative stabilization of the two conformers with gauche carboxylates at the expense of the anticonformer. The significant quantitative difference found between Na+ and K+ in basic solutions, as well as between calcium‐free and calcium‐containing solutions, may bear some relevance for the role of aspartate as a CNS neurotransmitter.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Neurochemistry|
|State||Published - Apr 1983|
- Alkaline chlorides
- Neurotransmitter conformation.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience