Influence of the Ionic Environment on the Conformation of Aspartic Acid and Possible Relevance to Its Neurotransmitter Action

Gennaro Esposito, Andrea Motta, Piero A. Temussi

Research output: Contribution to journalArticle

Abstract

The conformational changes of aspartic acid, a possible neurotransmitter, induced by increasing ionic strength were investigated by means of NMR spectros‐copy. The effects of Li, Na, K, and Cs chlorides in basic and neutral conditions were characterized. The effects of the presence of both Ca2+ and Na+ or K+ were also examined. The results always showed a relative stabilization of the two conformers with gauche carboxylates at the expense of the anticonformer. The significant quantitative difference found between Na+ and K+ in basic solutions, as well as between calcium‐free and calcium‐containing solutions, may bear some relevance for the role of aspartate as a CNS neurotransmitter.

Original languageEnglish (US)
Pages (from-to)903-907
Number of pages5
JournalJournal of Neurochemistry
Volume40
Issue number4
DOIs
StatePublished - Apr 1983

Keywords

  • Alkaline chlorides
  • Aspartate
  • Conformation
  • Neurotransmitter conformation.

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Influence of the Ionic Environment on the Conformation of Aspartic Acid and Possible Relevance to Its Neurotransmitter Action'. Together they form a unique fingerprint.

  • Cite this