Inhibition by L-ascorbate of bacterial mutagenesis induced by two N-nitroso compounds

Joseph B. Guttenplan

doi:10.1038/268368a0

Inhibition by L-ascorbate of bacterial mutagenesis induced by two N-nitroso compounds

Joseph B. Guttenplan

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

MANY chemicals are activated to carcinogens and mutagens by oxidative metabolism to alkylating agents¹. Ascorbic acid has been reported to protect against tumour induction in mice by 3-hydroxyanthranilic acid, which induced bladder tumours² and 7,12-dimethylbenzanthracene plus croton oil which induced skin tumours³. Ascorbic acid can also prevent the formation of carcinogenic N-nitroso compounds from nitrite and amines, in vivo⁴ and in vitro⁵. I report here that mutagenesis by two preformed N-nitroso compounds is effectively inhibited by ascorbic acid.

Original language	English (US)
Pages (from-to)	368-370
Number of pages	3
Journal	Nature
Volume	268
Issue number	5618
DOIs	https://doi.org/10.1038/268368a0
State	Published - 1977

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abstract = "MANY chemicals are activated to carcinogens and mutagens by oxidative metabolism to alkylating agents1. Ascorbic acid has been reported to protect against tumour induction in mice by 3-hydroxyanthranilic acid, which induced bladder tumours2 and 7,12-dimethylbenzanthracene plus croton oil which induced skin tumours3. Ascorbic acid can also prevent the formation of carcinogenic N-nitroso compounds from nitrite and amines, in vivo4 and in vitro5. I report here that mutagenesis by two preformed N-nitroso compounds is effectively inhibited by ascorbic acid.",

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AB - MANY chemicals are activated to carcinogens and mutagens by oxidative metabolism to alkylating agents1. Ascorbic acid has been reported to protect against tumour induction in mice by 3-hydroxyanthranilic acid, which induced bladder tumours2 and 7,12-dimethylbenzanthracene plus croton oil which induced skin tumours3. Ascorbic acid can also prevent the formation of carcinogenic N-nitroso compounds from nitrite and amines, in vivo4 and in vitro5. I report here that mutagenesis by two preformed N-nitroso compounds is effectively inhibited by ascorbic acid.

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Inhibition by L-ascorbate of bacterial mutagenesis induced by two N-nitroso compounds

Abstract

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