Inhibition of bacterial aggregation by serum- and blood-derived proteins

D. Malamud, C. Brown, R. Goldman

    Research output: Contribution to journalArticlepeer-review


    Human and animal sera contain potent inhibitors of saliva-mediated aggregation of oral streptococci. The inhibitors consist of a high-molecular-weight heat-labile factor and a lower-molecular-weight heat-activated factor. The latter appears to be serum albumin. Analyses of purified blood-derived proteins indicated that several high-molecular-weight proteins (fibrinogen, fibronectin, and ferritin) were able to inhibit aggregation at low concentrations. These data suggest that high-molecular-weight proteins may modulate the aggregation process.

    Original languageEnglish (US)
    Pages (from-to)386-390
    Number of pages5
    JournalInfection and Immunity
    Issue number1
    StatePublished - 1984

    ASJC Scopus subject areas

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases


    Dive into the research topics of 'Inhibition of bacterial aggregation by serum- and blood-derived proteins'. Together they form a unique fingerprint.

    Cite this