Inhibition of bacterial aggregation by serum- and blood-derived proteins

D. Malamud, C. Brown, R. Goldman

Research output: Contribution to journalArticlepeer-review


Human and animal sera contain potent inhibitors of saliva-mediated aggregation of oral streptococci. The inhibitors consist of a high-molecular-weight heat-labile factor and a lower-molecular-weight heat-activated factor. The latter appears to be serum albumin. Analyses of purified blood-derived proteins indicated that several high-molecular-weight proteins (fibrinogen, fibronectin, and ferritin) were able to inhibit aggregation at low concentrations. These data suggest that high-molecular-weight proteins may modulate the aggregation process.

Original languageEnglish (US)
Pages (from-to)386-390
Number of pages5
JournalInfection and Immunity
Issue number1
StatePublished - 1984

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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