Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based α helices

Deyun Wang; Min Lu; Paramjit S. Arora

doi:10.1002/anie.200704227

Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based α helices

Deyun Wang, Min Lu, Paramjit S. Arora

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Inhibition with a twist: An artificial α helix obtained by replacing an N-terminal main-chain i and i+4 hydrogen bond with a carbon-carbon bond (see structure) inhibits gp41-mediated cell fusion. This work suggests that hydrogen-bond-surrogate-derived helices may provide a general class of scaffolds for the generation of leads against viral entry. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	1879-1882
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	10
DOIs	https://doi.org/10.1002/anie.200704227
State	Published - Feb 22 2008

Keywords

Helical structures
Inhibitors
Molecular recognition
Peptidomimetics
Protein-protein interactions

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200704227

Cite this

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abstract = "Inhibition with a twist: An artificial α helix obtained by replacing an N-terminal main-chain i and i+4 hydrogen bond with a carbon-carbon bond (see structure) inhibits gp41-mediated cell fusion. This work suggests that hydrogen-bond-surrogate-derived helices may provide a general class of scaffolds for the generation of leads against viral entry. (Chemical Equation Presented).",

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AU - Lu, Min

AU - Arora, Paramjit S.

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AB - Inhibition with a twist: An artificial α helix obtained by replacing an N-terminal main-chain i and i+4 hydrogen bond with a carbon-carbon bond (see structure) inhibits gp41-mediated cell fusion. This work suggests that hydrogen-bond-surrogate-derived helices may provide a general class of scaffolds for the generation of leads against viral entry. (Chemical Equation Presented).

KW - Helical structures

KW - Inhibitors

KW - Molecular recognition

KW - Peptidomimetics

KW - Protein-protein interactions

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Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based α helices

Abstract

Keywords

ASJC Scopus subject areas

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