Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based α helices

Deyun Wang, Min Lu, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review


Inhibition with a twist: An artificial α helix obtained by replacing an N-terminal main-chain i and i+4 hydrogen bond with a carbon-carbon bond (see structure) inhibits gp41-mediated cell fusion. This work suggests that hydrogen-bond-surrogate-derived helices may provide a general class of scaffolds for the generation of leads against viral entry. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)1879-1882
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number10
StatePublished - Feb 22 2008


  • Helical structures
  • Inhibitors
  • Molecular recognition
  • Peptidomimetics
  • Protein-protein interactions

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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