Inhibition of Protein-Protein Interactions by Peptide Mimics

Jorge Becerril, Johanna M. Rodriguez, Pauline N. Wyrembak, Andrew D. Hamilton

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationProtein Surface Recognition
Subtitle of host publicationApproaches for Drug Discovery
PublisherJohn Wiley and Sons
Number of pages27
ISBN (Print)9780470059050
StatePublished - Nov 30 2010


  • Biological processes, and communication between proteins - specific surface interactions
  • Coactivator proteins, multiple repeats - conserved Leu-X-X-Leu-Leu (LXXLL) motif
  • Inhibitors of protein-protein interactions - allies in fight against HIV-1 epidemic
  • Nuclear estrogen receptor inhibition
  • Protein-protein interactions (PPIs) - normal cell function and regulating processes
  • Protein-protein interactions - mediated by binding epitope, residues as a-helix, β-turn or a β-sheet
  • Turns, common structural element - in PPIs, post-translational modifications and antibody recognition
  • p53/MDM2 interaction, another protein-protein interaction - in apoptotic pathway
  • protein-protein interaction inhibition - by peptide mimics
  • β-sheet, second major structural element - in globular proteins

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology

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