Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets

Pharmacology, Toxicology and Pharmaceutical Science

• Protein Tyrosine Phosphatase 100%
• Binding Site 33%
• Site-Directed Mutagenesis 33%
• Drug Development 33%
• Mitogen Activated Protein Kinase 3 33%
• Virtual Screening 33%

Biochemistry, Genetics and Molecular Biology

• Protein Tyrosine Phosphatase 100%
• Binding Site 33%
• Dynamics 33%
• Crystal Structure 33%
• Site-Directed Mutagenesis 33%

Keyphrases

• Cryptic Pocket 100%
• Striatal-enriched Protein Tyrosine Phosphatase 100%
• Phosphatase Inhibition 14%