Abstract
Cranberry fruit is a rich source of polyphenols, and has shown biological activities against Streptococcus mutans. In the present study, we examined the influence of extracts of flavonols (FLAV), anthocyanins (A) and proanthocyanidins (PAC) from cranberry on virulence factors involved in Streptococcus mutans biofilm development and acidogenicity. PAC and FLAV, alone or in combination, inhibited the surface-adsorbed glucosyltransferases and F-ATPases activities, and the acid production by S. mutans cells. Furthermore, biofilm development and acidogenicity were significantly affected by topical applications of PAC and FLAV (P<0.05). Anthocyanins were devoid of any significant biological effects. The flavonols are comprised of mostly quercetin glycosides, and the PAC are largely A-type oligomers of epicatechin. Our data show that proanthocyanidins and flavonols are the active constituents of cranberry against S. mutans.
Original language | English (US) |
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Pages (from-to) | 50-56 |
Number of pages | 7 |
Journal | FEMS Microbiology Letters |
Volume | 257 |
Issue number | 1 |
DOIs | |
State | Published - Apr 2006 |
Keywords
- Biofilms
- Cranberry
- Glucans
- Glycolysis
- Proanthocyanidins
- Streptococcus mutans
ASJC Scopus subject areas
- General Medicine