Inhibitory effects of parathyroid hormone on growth of osteogenic sarcoma cells

Nicola C. Partridge, Anne Louise Opie, Rebecca T. Opie, T. John Martin

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the bone resorbing hormone, parathyroid hormone (PTH), on the growth of malignant osteoblastic cells have been examined. The malignant osteoblastic cells were a clonal line (UMR 106) derived from a transplantable rat osteogenic sarcoma. The predominant effect of PTH at doses above 10-10 M was an inhibition of replication and DNA synthesis. Replication was decreased by PTH in both the presence or absence of serum and at various cell seeding densities. Both bovine PTH (1-84) and the synthetic hormone, human PTH (1-34), inhibited replication, but with bovine hormone being an order of magnitude more potent. The effects could be observed in as short a time as 6 hours with DNA synthesis and 24 hours with replication.

Original languageEnglish (US)
Pages (from-to)519-525
Number of pages7
JournalCalcified Tissue International
Volume37
Issue number5
DOIs
StatePublished - Sep 1985

Keywords

  • DNA synthesis
  • Osteoblast
  • Parathyroid hormone
  • Replication

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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