Inhibitory effects of parathyroid hormone on growth of osteogenic sarcoma cells

Nicola C. Partridge; Anne Louise Opie; Rebecca T. Opie; T. John Martin

doi:10.1007/BF02557835

Inhibitory effects of parathyroid hormone on growth of osteogenic sarcoma cells

Nicola C. Partridge, Anne Louise Opie, Rebecca T. Opie, T. John Martin

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of the bone resorbing hormone, parathyroid hormone (PTH), on the growth of malignant osteoblastic cells have been examined. The malignant osteoblastic cells were a clonal line (UMR 106) derived from a transplantable rat osteogenic sarcoma. The predominant effect of PTH at doses above 10^-10 M was an inhibition of replication and DNA synthesis. Replication was decreased by PTH in both the presence or absence of serum and at various cell seeding densities. Both bovine PTH (1-84) and the synthetic hormone, human PTH (1-34), inhibited replication, but with bovine hormone being an order of magnitude more potent. The effects could be observed in as short a time as 6 hours with DNA synthesis and 24 hours with replication.

Original language	English (US)
Pages (from-to)	519-525
Number of pages	7
Journal	Calcified Tissue International
Volume	37
Issue number	5
DOIs	https://doi.org/10.1007/BF02557835
State	Published - Sep 1985

Keywords

DNA synthesis
Osteoblast
Parathyroid hormone
Replication

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

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10.1007/BF02557835

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abstract = "The effects of the bone resorbing hormone, parathyroid hormone (PTH), on the growth of malignant osteoblastic cells have been examined. The malignant osteoblastic cells were a clonal line (UMR 106) derived from a transplantable rat osteogenic sarcoma. The predominant effect of PTH at doses above 10-10 M was an inhibition of replication and DNA synthesis. Replication was decreased by PTH in both the presence or absence of serum and at various cell seeding densities. Both bovine PTH (1-84) and the synthetic hormone, human PTH (1-34), inhibited replication, but with bovine hormone being an order of magnitude more potent. The effects could be observed in as short a time as 6 hours with DNA synthesis and 24 hours with replication.",

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AU - Partridge, Nicola C.

AU - Louise Opie, Anne

AU - Opie, Rebecca T.

AU - John Martin, T.

PY - 1985/9

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N2 - The effects of the bone resorbing hormone, parathyroid hormone (PTH), on the growth of malignant osteoblastic cells have been examined. The malignant osteoblastic cells were a clonal line (UMR 106) derived from a transplantable rat osteogenic sarcoma. The predominant effect of PTH at doses above 10-10 M was an inhibition of replication and DNA synthesis. Replication was decreased by PTH in both the presence or absence of serum and at various cell seeding densities. Both bovine PTH (1-84) and the synthetic hormone, human PTH (1-34), inhibited replication, but with bovine hormone being an order of magnitude more potent. The effects could be observed in as short a time as 6 hours with DNA synthesis and 24 hours with replication.

AB - The effects of the bone resorbing hormone, parathyroid hormone (PTH), on the growth of malignant osteoblastic cells have been examined. The malignant osteoblastic cells were a clonal line (UMR 106) derived from a transplantable rat osteogenic sarcoma. The predominant effect of PTH at doses above 10-10 M was an inhibition of replication and DNA synthesis. Replication was decreased by PTH in both the presence or absence of serum and at various cell seeding densities. Both bovine PTH (1-84) and the synthetic hormone, human PTH (1-34), inhibited replication, but with bovine hormone being an order of magnitude more potent. The effects could be observed in as short a time as 6 hours with DNA synthesis and 24 hours with replication.

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KW - Parathyroid hormone

KW - Replication

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Inhibitory effects of parathyroid hormone on growth of osteogenic sarcoma cells

Abstract

Keywords

ASJC Scopus subject areas

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