Innovative Programmable Bio-Nano-Chip Digitizes Biology Using Sensors That Learn Bridging Biomarker Discovery and Clinical Implementation

Nicolaos J. Christodoulides, Michael P. McRae, Timothy J. Abram, Glennon W. Simmons, John T. McDevitt

Research output: Contribution to journalReview articlepeer-review

Abstract

The lack of standard tools and methodologies and the absence of a streamlined multimarker approval process have hindered the translation rate of new biomarkers into clinical practice for a variety of diseases afflicting humankind. Advanced novel technologies with superior analytical performance and reduced reagent costs, like the programmable bio-nano-chip system featured in this article, have potential to change the delivery of healthcare. This universal platform system has the capacity to digitize biology, resulting in a sensor modality with a capacity to learn. With well-planned device design, development, and distribution plans, there is an opportunity to translate benchtop discoveries in the genomics, proteomics, metabolomics, and glycomics fields by transforming the information content of key biomarkers into actionable signatures that can empower physicians and patients for a better management of healthcare. While the process is complicated and will take some time, showcased here are three application areas for this flexible platform that combines biomarker content with minimally invasive or non-invasive sampling, such as brush biopsy for oral cancer risk assessment; serum, plasma, and small volumes of blood for the assessment of cardiac risk and wellness; and oral fluid sampling for drugs of abuse testing at the point of need.

Original languageEnglish (US)
Article number110
JournalFrontiers in Public Health
Volume5
DOIs
StatePublished - May 22 2017

Keywords

  • biomarkers
  • in vitro diagnostics
  • medical microdevices
  • non-invasive sampling
  • point of care

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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