Inorganic polyphosphate: An unusual suspect of the mitochondrial permeability transition mystery

Lea K. Seidlmayer, Lothar A. Blatter, Evgeny Pavlov, Elena N. Dedkova

Research output: Contribution to journalArticle

Abstract

Inorganic polyphosphate (polyP) is a naturally occurring polyanion made of ten to several hundred orthophosphates (Pi) linked together by phosphoanhydride bonds. PolyP is ubiquitously present in all organisms from bacteria to humans. Specific physiological roles of polyP vary dramatically depending on its size, concentration, tissue and subcellular localization. Recently we reported that mitochondria of ventricular myocytes contain significant amounts (280 ± 60 pmol/mg of protein) of polyP with an average length of 25 orthophosphates, and that polyP is involved in Ca 2+-dependent activation of the mitochondrial permeability transition pore (mPTP). Here we extend our study to demonstrate the involvement of mitochondrial polyP in cardiac cell death. Furthermore, we show that polyP levels depend on the activity of the respiratory chain and are lower in myocytes from failing hearts. We conclude that polyP is a dynamically regulated macromolecule that plays an important role in mPTP-dependent cell death pathway.

Original languageEnglish (US)
Pages (from-to)463-467
Number of pages5
JournalChannels
Volume6
Issue number6
DOIs
StatePublished - 2012

Keywords

  • Calcium
  • Cell death
  • DAPI
  • Exopolyphosphatase
  • Hypercontracture
  • Inorganic polyphosphate
  • Mitochondria
  • Permeability transition pore
  • Ventricular myocytes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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