Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology

Maria A. Neginskaya; Evgeny V. Pavlov

doi:10.1007/978-3-031-01237-2_2

Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology

Maria A. Neginskaya, Evgeny V. Pavlov

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

In this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.

Original language	English (US)
Pages (from-to)	15-26
Number of pages	12
Journal	Progress in molecular and subcellular biology
Volume	61
DOIs	https://doi.org/10.1007/978-3-031-01237-2_2
State	Published - 2022

Keywords

ATP
Calcium
Mitochondrial function
Oxidative phosphorylation
Permeability transition pore
Polyhydroxybutyrate
PolyP hydrolyzing enzyme
Polyphosphate kinase

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-031-01237-2_2

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abstract = "In this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.",

keywords = "ATP, Calcium, Mitochondrial function, Oxidative phosphorylation, Permeability transition pore, Polyhydroxybutyrate, PolyP hydrolyzing enzyme, Polyphosphate kinase",

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AU - Pavlov, Evgeny V.

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AB - In this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.

KW - ATP

KW - Calcium

KW - Mitochondrial function

KW - Oxidative phosphorylation

KW - Permeability transition pore

KW - Polyhydroxybutyrate

KW - PolyP hydrolyzing enzyme

KW - Polyphosphate kinase

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JF - Progress in molecular and subcellular biology

ER -

Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology

Abstract

Keywords

ASJC Scopus subject areas

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