Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology

Maria A. Neginskaya, Evgeny V. Pavlov

Research output: Contribution to journalArticlepeer-review


In this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.

Original languageEnglish (US)
Pages (from-to)15-26
Number of pages12
JournalProgress in molecular and subcellular biology
StatePublished - 2022


  • ATP
  • Calcium
  • Mitochondrial function
  • Oxidative phosphorylation
  • Permeability transition pore
  • Polyhydroxybutyrate
  • PolyP hydrolyzing enzyme
  • Polyphosphate kinase

ASJC Scopus subject areas

  • Medicine(all)


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