Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology

Maria A. Neginskaya, Evgeny V. Pavlov

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.

Original languageEnglish (US)
Title of host publicationProgress in Molecular and Subcellular Biology
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages12
StatePublished - 2022

Publication series

NameProgress in Molecular and Subcellular Biology
ISSN (Print)0079-6484
ISSN (Electronic)2197-8484


  • ATP
  • Calcium
  • Mitochondrial function
  • Oxidative phosphorylation
  • Permeability transition pore
  • Polyhydroxybutyrate
  • PolyP hydrolyzing enzyme
  • Polyphosphate kinase

ASJC Scopus subject areas

  • General Medicine


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