Insights into miRNA regulation of the human glycome

Brian T. Kasper, Sujeethraj Koppolu, Lara K. Mahal

Research output: Contribution to journalArticle

Abstract

Glycosylation is an intricate process requiring the coordinated action of multiple proteins, including glycosyltransferases, glycosidases, sugar nucleotide transporters and trafficking proteins. Work by several groups points to a role for microRNA (miRNA) in controlling the levels of specific glycosyltransferases involved in cancer, neural migration and osteoblast formation. Recent work in our laboratory suggests that miRNA are a principal regulator of the glycome, translating genomic information into the glycocode through tuning of enzyme levels. Herein we overlay predicted miRNA regulation of glycosylation related genes (glycogenes) onto maps of the common N-linked and O-linked glycan biosynthetic pathways to identify key regulatory nodes of the glycome. Our analysis provides insights into glycan regulation and suggests that at the regulatory level, glycogenes are non-redundant.

Original languageEnglish (US)
Pages (from-to)774-779
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume445
Issue number4
DOIs
StatePublished - Mar 21 2014

Keywords

  • Carbohydrate pathways
  • Glycan biosynthesis
  • Glycan regulation
  • Glycogenes
  • Glycosylation
  • MicroRNA
  • miRNA

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Insights into miRNA regulation of the human glycome'. Together they form a unique fingerprint.

  • Cite this