Abstract
Recent advances in next-generation DNA sequencing and proteomics provide an unprecedented ability to survey mRNA and protein abundances. Such proteome-wide surveys are illuminating the extent to which different aspects of gene expression help to regulate cellular protein abundances. Current data demonstrate a substantial role for regulatory processes occurring after mRNA is made-that is, post-transcriptional, translational and protein degradation regulation-in controlling steady-state protein abundances. Intriguing observations are also emerging in relation to cells following perturbation, single-cell studies and the apparent evolutionary conservation of protein and mRNA abundances. Here, we summarize current understanding of the major factors regulating protein expression.
Original language | English (US) |
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Pages (from-to) | 227-232 |
Number of pages | 6 |
Journal | Nature Reviews Genetics |
Volume | 13 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2012 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)