Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

Christine Vogel, Edward M. Marcotte

Research output: Contribution to journalArticlepeer-review

Abstract

Recent advances in next-generation DNA sequencing and proteomics provide an unprecedented ability to survey mRNA and protein abundances. Such proteome-wide surveys are illuminating the extent to which different aspects of gene expression help to regulate cellular protein abundances. Current data demonstrate a substantial role for regulatory processes occurring after mRNA is made-that is, post-transcriptional, translational and protein degradation regulation-in controlling steady-state protein abundances. Intriguing observations are also emerging in relation to cells following perturbation, single-cell studies and the apparent evolutionary conservation of protein and mRNA abundances. Here, we summarize current understanding of the major factors regulating protein expression.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalNature Reviews Genetics
Volume13
Issue number4
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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