Insulin-Like Growth Factor 1 Physiology. Lessons from Mouse Models.

Shoshana Yakar, Martin L. Adamo

Research output: Contribution to journalReview articlepeer-review


Insulin-like growth factor 1 (IGF-1) is a pleiotropic polypeptide. Its expression is tightly regulated and it plays significant roles during early development, maturation, and adulthood. This article discusses the roles of IGF-1 in determination of body size, skeletal acquisition, muscle growth, carbohydrate metabolism, and longevity, as learned from mouse models.

Original languageEnglish (US)
Pages (from-to)231-247
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Issue number2
StatePublished - Jun 2012


  • IGF-1
  • Insulin-like growth factor 1
  • Mouse models
  • Physiology

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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