TY - JOUR
T1 - Insulin-like growth factor-I
T2 - Compartmentalization within the somatotropic axis?
AU - Butler, Andrew A.
AU - Yakar, Shoshana
AU - LeRoith, Derek
PY - 2002/4
Y1 - 2002/4
N2 - Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.
AB - Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.
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U2 - 10.1152/nips.01351.2001
DO - 10.1152/nips.01351.2001
M3 - Article
C2 - 11909998
AN - SCOPUS:0036544712
SN - 0886-1714
VL - 17
SP - 82
EP - 85
JO - News in Physiological Sciences
JF - News in Physiological Sciences
IS - 2
ER -