TY - JOUR
T1 - Insulin-like growth factor-I receptor signal transduction
T2 - At the interface between physiology and cell biology
AU - Butler, Andrew A.
AU - Yakar, Shoshana
AU - Gewolb, Ira H.
AU - Karas, Michael
AU - Okubo, Yumiko
AU - LeRoith, Derek
PY - 1998
Y1 - 1998
N2 - The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. Copyright (C) 1998 Elsevier Science Inc.
AB - The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. Copyright (C) 1998 Elsevier Science Inc.
KW - Cell biology
KW - Insulin-like growth factor-I receptor
KW - Physiology
KW - Signal transduction
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U2 - 10.1016/S0305-0491(98)10106-2
DO - 10.1016/S0305-0491(98)10106-2
M3 - Article
C2 - 9972281
AN - SCOPUS:0031743951
VL - 121
SP - 19
EP - 26
JO - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
JF - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
SN - 0305-0491
IS - 1
ER -