Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology

Andrew A. Butler, Shoshana Yakar, Ira H. Gewolb, Michael Karas, Yumiko Okubo, Derek LeRoith

Research output: Contribution to journalArticlepeer-review

Abstract

The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume121
Issue number1
DOIs
StatePublished - 1998

Keywords

  • Cell biology
  • Insulin-like growth factor-I receptor
  • Physiology
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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