Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology

Andrew A. Butler; Shoshana Yakar; Ira H. Gewolb; Michael Karas; Yumiko Okubo; Derek LeRoith

doi:10.1016/S0305-0491(98)10106-2

Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology

Andrew A. Butler, Shoshana Yakar, Ira H. Gewolb, Michael Karas, Yumiko Okubo, Derek LeRoith

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. Copyright (C) 1998 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	19-26
Number of pages	8
Journal	Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume	121
Issue number	1
DOIs	https://doi.org/10.1016/S0305-0491(98)10106-2
State	Published - 1998

Keywords

Cell biology
Insulin-like growth factor-I receptor
Physiology
Signal transduction

ASJC Scopus subject areas

Biochemistry
Physiology
Molecular Biology

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10.1016/S0305-0491(98)10106-2

Cite this

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title = "Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology",

abstract = "The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. Copyright (C) 1998 Elsevier Science Inc.",

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T2 - At the interface between physiology and cell biology

AU - Butler, Andrew A.

AU - Yakar, Shoshana

AU - Gewolb, Ira H.

AU - Karas, Michael

AU - Okubo, Yumiko

AU - LeRoith, Derek

PY - 1998

Y1 - 1998

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AB - The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. Copyright (C) 1998 Elsevier Science Inc.

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KW - Signal transduction

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Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology

Abstract

Keywords

ASJC Scopus subject areas

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