@inproceedings{366799bf805e4b2a9f46a698fe7e9a34,
title = "Integrated gut-liver on a chip for modelling non-alcoholic fatty liver disease in vitro",
abstract = "Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, but there is still no effective drugs, due to the lack of proper in vitro models. Here we report an integrated gut-liver on a chip (iGL Chip) to recapitulate NAFLD via gut-liver axis interaction in vitro by medium circulation of a precise closed-loop microfluidic channel integrated with a micro pump. Thus, the iGL Chip showed the intercellular lipid accumulation, resulting reduction of cell viability, one of NAFLD phenotypes. This system offers the potential for developing more human related disease model.",
keywords = "Body on a Chip, Disease Modelling, Gut-Liver on a Chip, Non-Alcoholic Fatty Liver Disease",
author = "Jiandong Yang and Yoshikazu Hirai and Kamei, {Ken Ichiro} and Toshiyuki Tsuchiya and Osamu Tabata",
note = "Publisher Copyright: {\textcopyright} 2019 CBMS-0001.; 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",
year = "2019",
language = "English (US)",
series = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
publisher = "Chemical and Biological Microsystems Society",
pages = "376--377",
booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
}