Integrated gut-liver on a chip for modelling non-alcoholic fatty liver disease in vitro

Jiandong Yang, Yoshikazu Hirai, Ken Ichiro Kamei, Toshiyuki Tsuchiya, Osamu Tabata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, but there is still no effective drugs, due to the lack of proper in vitro models. Here we report an integrated gut-liver on a chip (iGL Chip) to recapitulate NAFLD via gut-liver axis interaction in vitro by medium circulation of a precise closed-loop microfluidic channel integrated with a micro pump. Thus, the iGL Chip showed the intercellular lipid accumulation, resulting reduction of cell viability, one of NAFLD phenotypes. This system offers the potential for developing more human related disease model.

Original languageEnglish (US)
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages376-377
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: Oct 27 2019Oct 31 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period10/27/1910/31/19

Keywords

  • Body on a Chip
  • Disease Modelling
  • Gut-Liver on a Chip
  • Non-Alcoholic Fatty Liver Disease

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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