Abstract
The interactions of dimethyldiazaperopyrenium dication (1) with DNA have been studied by spectroscopic methods: absorption, static and dynamic fluorescence, and linear dichroism. 1 binds strongly to DNA at 250 mM NaCl, with a higher affinity for G-C pairs as compared to A-T pairs. The dye fluorescence is enhanced when it is bound to A-T pairs, whereas the emission is quenched in the vicinity of G-C pairs. Evidence for intercalation has been obtained via energy transfer and linear dichroism measurements.
Original language | English (US) |
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Pages (from-to) | 3234-3242 |
Number of pages | 9 |
Journal | Biochemistry |
Volume | 28 |
Issue number | 8 |
DOIs | |
State | Published - Apr 1989 |
ASJC Scopus subject areas
- Biochemistry