Interactive design and manipulation of macro-molecular architecture utilizing nucleic acid junctions

Nadrian C. Seeman

doi:10.1016/0263-7855(85)80001-1

Interactive design and manipulation of macro-molecular architecture utilizing nucleic acid junctions

Nadrian C. Seeman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A program is introduced for the design of macromolecular structures using branched nucleic acid junctions as building blocks. This can result in unexpected features in the designed molecules, several examples of which are illustrated. The program allows interactive construction of models constrained by double-helical connecting rods between vertices. The logical structure of the design process is based on the single helical segment, rather than on the junction, as the fundamental unit. The file structure permits storage of both molecules and instruction protocols.

Original language	English (US)
Pages (from-to)	34-39
Number of pages	6
Journal	Journal of Molecular Graphics
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0263-7855(85)80001-1
State	Published - Jun 1985

Keywords

macromolecular architecture
nucleic acid junctions
sticky-ended ligation

ASJC Scopus subject areas

Biophysics
Biochemistry

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10.1016/0263-7855(85)80001-1

Cite this

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title = "Interactive design and manipulation of macro-molecular architecture utilizing nucleic acid junctions",

abstract = "A program is introduced for the design of macromolecular structures using branched nucleic acid junctions as building blocks. This can result in unexpected features in the designed molecules, several examples of which are illustrated. The program allows interactive construction of models constrained by double-helical connecting rods between vertices. The logical structure of the design process is based on the single helical segment, rather than on the junction, as the fundamental unit. The file structure permits storage of both molecules and instruction protocols.",

keywords = "macromolecular architecture, nucleic acid junctions, sticky-ended ligation",

author = "Seeman, {Nadrian C.}",

note = "Funding Information: This work has been supportedb y Grants GM-29554 and ES-00117f rom the National Instituteso f Health. The author would like to thank the computerc entreo f the StateU niversity of New York at Albany for the use of its Sperry 110018~2 mputer. The author is the recipient of a ResearchC areer DevelopmentA ward from the National Instituteo f Health USPHS. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1985",

month = jun,

doi = "10.1016/0263-7855(85)80001-1",

language = "English (US)",

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AU - Seeman, Nadrian C.

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PY - 1985/6

Y1 - 1985/6

N2 - A program is introduced for the design of macromolecular structures using branched nucleic acid junctions as building blocks. This can result in unexpected features in the designed molecules, several examples of which are illustrated. The program allows interactive construction of models constrained by double-helical connecting rods between vertices. The logical structure of the design process is based on the single helical segment, rather than on the junction, as the fundamental unit. The file structure permits storage of both molecules and instruction protocols.

AB - A program is introduced for the design of macromolecular structures using branched nucleic acid junctions as building blocks. This can result in unexpected features in the designed molecules, several examples of which are illustrated. The program allows interactive construction of models constrained by double-helical connecting rods between vertices. The logical structure of the design process is based on the single helical segment, rather than on the junction, as the fundamental unit. The file structure permits storage of both molecules and instruction protocols.

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KW - sticky-ended ligation

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Interactive design and manipulation of macro-molecular architecture utilizing nucleic acid junctions

Abstract

Keywords

ASJC Scopus subject areas

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