Interactive design and manipulation of macro-molecular architecture utilizing nucleic acid junctions

Research output: Contribution to journalArticle

Abstract

A program is introduced for the design of macromolecular structures using branched nucleic acid junctions as building blocks. This can result in unexpected features in the designed molecules, several examples of which are illustrated. The program allows interactive construction of models constrained by double-helical connecting rods between vertices. The logical structure of the design process is based on the single helical segment, rather than on the junction, as the fundamental unit. The file structure permits storage of both molecules and instruction protocols.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalJournal of Molecular Graphics
Volume3
Issue number2
DOIs
StatePublished - Jun 1985

Keywords

  • macromolecular architecture
  • nucleic acid junctions
  • sticky-ended ligation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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