Abstract
An interfacial photopolymerization method for the intravascular application of thin hydrogel barriers was developed. The hydrogels are well suited for localized intravascular delivery of hydrophilic macromolecules dissolved in the aqueous precursor solution and entrapped in the hydrogel after illumination. It was found that when platelet derived growth factor (PDGF) was locally delivered from the photopolymerized hydrogel after vascular injury, the thickness of the intimal layer of the arterial wall increased markedly. A protein can be delivered from a photopolymerized hydrogel while retaining its biological activity and the released protein can permeate through the vessel wall to act upon its target, medial smooth muscle cells.
| Original language | English (US) |
|---|---|
| Pages | 645 |
| Number of pages | 1 |
| State | Published - 1996 |
| Event | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996 |
Other
| Other | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) |
|---|---|
| City | Toronto, Can |
| Period | 5/29/96 → 6/2/96 |
ASJC Scopus subject areas
- General Materials Science