Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Cristina Cantarutti; Gijo Raj; Federico Fogolari; Sofia Giorgetti; Alessandra Corazza; Vittorio Bellotti; Panče Naumov; Gennaro Esposito

doi:10.1039/c8cc01053f

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Cristina Cantarutti, Gijo Raj, Federico Fogolari, Sofia Giorgetti, Alessandra Corazza, Vittorio Bellotti, Panče Naumov, Gennaro Esposito

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

Original language	English (US)
Pages (from-to)	5422-5425
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	43
DOIs	https://doi.org/10.1039/c8cc01053f
State	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc01053f

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abstract = "Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.",

author = "Cristina Cantarutti and Gijo Raj and Federico Fogolari and Sofia Giorgetti and Alessandra Corazza and Vittorio Bellotti and Pan{\v c}e Naumov and Gennaro Esposito",

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AU - Cantarutti, Cristina

AU - Raj, Gijo

AU - Fogolari, Federico

AU - Giorgetti, Sofia

AU - Corazza, Alessandra

AU - Bellotti, Vittorio

AU - Naumov, Panče

AU - Esposito, Gennaro

PY - 2018

Y1 - 2018

N2 - Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

AB - Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Abstract

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