Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Cristina Cantarutti, Gijo Raj, Federico Fogolari, Sofia Giorgetti, Alessandra Corazza, Vittorio Bellotti, Panče Naumov, Gennaro Esposito

Research output: Contribution to journalArticle

Abstract

Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

Original languageEnglish (US)
Pages (from-to)5422-5425
Number of pages4
JournalChemical Communications
Volume54
Issue number43
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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