Interferon Production by Cultured Murine Splenocytes in Response to Influenza Virus-Infected Cells

Carol Shoshkes Reiss, Lisa L.m. Liu, Solomon L. Mowshowitz

Research output: Contribution to journalArticle

Abstract

Murine splenic lymphocytes cultured for 18 h with either irradiated syngeneic cells infected with influenza A/PR/8/34 virus or irradiated allogeneic cells infected with the same virus release significant quantities of alpha interferon (IFN-α) in 24 h. Uninfected allogeneic cells, which are potent stimulators of both lymphocyte proliferation and cytolytic T lymphocytes, failed to induce detectable level of IFN under the same conditions. Cells derived from naive and virus-primed animals gave similar responses to these stimulae. The phenotype of the cells interacting in vitro to these conditions is discussed.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalJournal of Interferon Research
Volume4
Issue number1
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology
  • Virology

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