TY - JOUR
T1 - Interferon Production by Cultured Murine Splenocytes in Response to Influenza Virus-Infected Cells
AU - Reiss, Carol Shoshkes
AU - Liu, Lisa L.m.
AU - Mowshowitz, Solomon L.
PY - 1984
Y1 - 1984
N2 - Murine splenic lymphocytes cultured for 18 h with either irradiated syngeneic cells infected with influenza A/PR/8/34 virus or irradiated allogeneic cells infected with the same virus release significant quantities of alpha interferon (IFN-α) in 24 h. Uninfected allogeneic cells, which are potent stimulators of both lymphocyte proliferation and cytolytic T lymphocytes, failed to induce detectable level of IFN under the same conditions. Cells derived from naive and virus-primed animals gave similar responses to these stimulae. The phenotype of the cells interacting in vitro to these conditions is discussed.
AB - Murine splenic lymphocytes cultured for 18 h with either irradiated syngeneic cells infected with influenza A/PR/8/34 virus or irradiated allogeneic cells infected with the same virus release significant quantities of alpha interferon (IFN-α) in 24 h. Uninfected allogeneic cells, which are potent stimulators of both lymphocyte proliferation and cytolytic T lymphocytes, failed to induce detectable level of IFN under the same conditions. Cells derived from naive and virus-primed animals gave similar responses to these stimulae. The phenotype of the cells interacting in vitro to these conditions is discussed.
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U2 - 10.1089/jir.1984.4.81
DO - 10.1089/jir.1984.4.81
M3 - Article
C2 - 6325553
AN - SCOPUS:0021269716
VL - 4
SP - 81
EP - 89
JO - Journal of Interferon Research
JF - Journal of Interferon Research
SN - 0197-8357
IS - 1
ER -