Interleukin-12 promotes recovery from viral encephalitis

Takashi Komatsu, Maria Barna, Carol S. Reiss

Research output: Contribution to journalArticle

Abstract

Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homogenates and diminished immunohistochemical detection of VSV antigens in tissue sections; 4) earlier and increased CNS expression of types 1, 2, and 3 nitric oxide synthase (NOS) and both major histocompatibility complex (MHC) class I and class II antigens; 5) earlier and increased blood and CNS levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). These results suggest that IL-12 enhances recovery from VSV infection of the CNS.

Original languageEnglish (US)
Pages (from-to)35-47
Number of pages13
JournalViral Immunology
Volume10
Issue number1
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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