A 1H and 13C NMR study of the interaction between sodium deoxycholate (NaDC) micelles and a nitroxide probe (cholestane spin-label, CSL) is presented. It is shown that CSL primarily interacts with the β face of NaDC. The 1H NMR relaxation data enable the spatial geometry of the interaction to be defined. van der Waals energy calculations show that the CSL-NaDC interaction corresponds to a minimum if a helical model, previously proposed, is assumed for the NaDC micelle. At high concentrations of CSL, the CSL-NaDC interaction changes and the α face of NaDC may also become involved in the interaction.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry