Interneuron cell types are fit to function

Adam Kepecs, Gordon Fishell

Research output: Contribution to journalReview articlepeer-review

Abstract

Understanding brain circuits begins with an appreciation of their component parts-the cells. Although GABAergic interneurons are a minority population within the brain, they are crucial for the control of inhibition. Determining the diversity of these interneurons has been a central goal of neurobiologists, but this amazing cell type has so far defied a generalized classification system. Interneuron complexity within the telencephalon could be simplified by viewing them as elaborations of a much more finite group of developmentally specified cardinal classes that become further specialized as they mature. Our perspective emphasizes that the ultimate goal is to dispense with classification criteria and directly define interneuron types by function.

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalNature
Volume505
Issue number7483
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • General

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