Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons

György Buzsáki, Caroline Geisler, Darrell A. Henze, Xiao Jing Wang

Research output: Contribution to journalReview article

Abstract

The performance of the brain is constrained by wiring length and maintenance costs. The apparently inverse relationship between number of neurons in the various interneuron classes and the spatial extent of their axon trees suggests a mathematically definable organization, reminiscent of 'small-world' or scale-free networks observed in other complex systems. The wiring-economy-based classification of cortical inhibitory interneurons is supported by the distinct physiological patterns of class members in the intact brain. The complex wiring of diverse interneuron classes could represent an economic solution for supporting global synchrony and oscillations at multiple timescales with minimum axon length.

Original languageEnglish (US)
Pages (from-to)186-193
Number of pages8
JournalTrends in Neurosciences
Volume27
Issue number4
DOIs
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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