@article{16a7cb6515ae4b62a1b6b4dbb8931432,
title = "Intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer measurements using handheld optical coherence tomography in children with optic pathway gliomas",
abstract = "Purpose: To determine the intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer thickness measures using handheld optical coherence tomography (OCT) in sedated children with optic pathway gliomas and/or neurofibromatosis type 1 (NF1).Design: Prospective longitudinal cohort study.Methods: Children with sporadic optic pathway gliomas and/or NF1 who had ≥2 volumes acquired over the macula using handheldOCT during sedation for clinically indicated magnetic resonance imaging were eligible for the intra-visit cohort.Children with repeat handheldOCT imagingwithin 6monthswere eligible for the inter-visit cohort. Total retinal thickness and ganglion cell-inner plexiform layer thickness were measured using custom-designed automated segmentation software. Reproducibility was compared across average and anatomic quadrant by calculating the coefficient of variation (CV) and intraclass correlation coefficient (ICC).Results: Forty-two subjects (median age 5.4 years, range 0.8-12.7 years) contributed 45 eyes to the intravisit cohort. Thirty-one subject eyes had normal vision and 14 had abnormal vision (decreased visual acuity and/ or visual field). Average and quadrant ganglion cell-inner plexiform layer measures demonstrated CVs ≤4.5% with excellent ICCs (>0.935). The superior quadrant CV differed between subjects with (4.4%) and without (2.1%) vision loss (P <.05). Twenty-five subject eyes were eligible for the inter-visit cohort, demonstrating CVs from 1.6% to 5.2%. Inter-visit ICCs were excellent (0.955-0.995).Discussion: Handheld OCT imaging in sedated children with optic pathway gliomas produces highly reproducible measures of ganglion cell-inner plexiform layer thickness.",
author = "Avery, {Robert A.} and Avital Cnaan and Schuman, {Joel S.} and Chen, {Chieh Li} and Glaug, {Natalie C.} and Packer, {Roger J.} and Quinn, {Graham E.} and Hiroshi Ishikawa",
note = "Funding Information: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Financial disclosures: Dr Schuman receives royalties for intellectual property licensed by Massachusetts Institute of Technology and Massachusetts Eye and Ear Infirmary to Zeiss. This article was supported by grants from the National Eye Institute/National Institutes of Health , Bethesda, Maryland ( K23-EY022673 , RAA), the National Institutes of Health/National Eye Institute Pediatric Research Loan repayment program (R.A.A.), “Clinical Research Award” from the Children's Tumor Foundation , New York, New York (R.A.A.), the Gilbert Family Neurofibromatosis Institute ,Washington, DC (R.A.A., R.J.P.), the National Center for Advancing Translational Sciences/National Institutes of Health UL1TR000075 (A.C.), Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health , Bethesda, Maryland P30 HD040677 (A.C.), National Institutes of Health R01-EY013178 and P30-008098 (H.I., J.S.S.), The Eye and Ear Foundation of Pittsburgh , Pittsburgh, Pennsylvania (H.I., J.S.S.), and an unrestricted grant from Research to Prevent Blindness , New York, New York (H.I., J.S.S.). Contributions of authors: design of the study (R.A.A., A.C., G.E.Q., H.I.), conduct of the study (R.A.A., C.-L.C., N.C.G., H.I.); collection, management, analysis, and interpretation of the data (R.A.A., A.C., J.S.S., C.-L.C., N.C.G., R.J.P., G.E.Q., H.I.); preparation, approval, and review of the manuscript (R.A.A., A.C., J.S.S., C.-L.C., N.C.G., R.J.P., G.E.Q., H.I.). Publisher Copyright: {\textcopyright} 2014 by Elsevier Inc. All rights reserved.",
year = "2014",
month = nov,
day = "1",
doi = "10.1016/j.ajo.2014.07.029",
language = "English (US)",
volume = "158",
pages = "916--923.e1",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5",
}