TY - JOUR
T1 - Intracellular Fluid Mechanics
T2 - Coupling Cytoplasmic Flow with Active Cytoskeletal Gel
AU - Mogilner, Alex
AU - Manhart, Angelika
N1 - Publisher Copyright:
© 2018 by Annual Reviews. All rights reserved.
PY - 2018/1/5
Y1 - 2018/1/5
N2 - The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the viscoelastic deforming cytoskeleton play key roles in cell physiology. We review mathematical models of intracellular fluid mechanics, from cytoplasmic fluid flows, to the flow of a viscous active cytoskeletal gel, to models of two-phase poroviscous flows, to poroelastic models. We discuss application of these models to cell biological phenomena, such as organelle positioning, blebbing, and cell motility. We also discuss challenges of understanding fluid mechanics on the cellular scale.
AB - The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the viscoelastic deforming cytoskeleton play key roles in cell physiology. We review mathematical models of intracellular fluid mechanics, from cytoplasmic fluid flows, to the flow of a viscous active cytoskeletal gel, to models of two-phase poroviscous flows, to poroelastic models. We discuss application of these models to cell biological phenomena, such as organelle positioning, blebbing, and cell motility. We also discuss challenges of understanding fluid mechanics on the cellular scale.
KW - Actin
KW - Active polar gel
KW - Blebs
KW - Cytoplasmic fluid flow
KW - Free moving boundary
KW - Myosin
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U2 - 10.1146/annurev-fluid-010816-060238
DO - 10.1146/annurev-fluid-010816-060238
M3 - Review article
AN - SCOPUS:85040309574
SN - 0066-4189
VL - 50
SP - 347
EP - 370
JO - Annual Review of Fluid Mechanics
JF - Annual Review of Fluid Mechanics
ER -