Intracellular Fluid Mechanics: Coupling Cytoplasmic Flow with Active Cytoskeletal Gel

Alex Mogilner, Angelika Manhart

Research output: Contribution to journalReview articlepeer-review


The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the viscoelastic deforming cytoskeleton play key roles in cell physiology. We review mathematical models of intracellular fluid mechanics, from cytoplasmic fluid flows, to the flow of a viscous active cytoskeletal gel, to models of two-phase poroviscous flows, to poroelastic models. We discuss application of these models to cell biological phenomena, such as organelle positioning, blebbing, and cell motility. We also discuss challenges of understanding fluid mechanics on the cellular scale.

Original languageEnglish (US)
Pages (from-to)347-370
Number of pages24
JournalAnnual Review of Fluid Mechanics
StatePublished - Jan 5 2018


  • Actin
  • Active polar gel
  • Blebs
  • Cytoplasmic fluid flow
  • Free moving boundary
  • Myosin

ASJC Scopus subject areas

  • Condensed Matter Physics


Dive into the research topics of 'Intracellular Fluid Mechanics: Coupling Cytoplasmic Flow with Active Cytoskeletal Gel'. Together they form a unique fingerprint.

Cite this